Nonclinical Pharmacokinetics

Nonclinical Pharmacokinetics

Scinovo has four technologic platforms to support drug pharmocokinetics investigations from the stage of discovery to nonclinical development, including LC-MS/MS platform, immunoassay platform, cell-based biology platform and molecular biology platform. Our professional knowledge and extensive experience could provide excellent service for clients to satisfy IND application. Drug's absorption, distribution, mebabolism and excretion (ADME) and PK could be studied. Scinovo hold the goal of providing scientific, high-quality and high efficient services, as well as providing advanced study design support to face some critical challenges. Services of nonclinical DMPK studies are listed as followings: 


In Vitro Studies

In Vitro Studies

· Permeability
· Plasma protein binding of different species
· Distribution in blood/plasma of different species
· Metabolic stability of different species
· Metabolite identification and profiling 
· Phentyping-CYP450s and UGTs
· Enzymes-CYP450s inhibition and induction
· Transporters-Substrate and inhibitor studies
· Metabolism and transporters mediated drug-drug interactions 

In vivo Studies

In vivo Studies

· Meabolite identification and quantitation
· Plasma PK
· Tissue distribution
· Excretion
· Mass balance
· Drug-drug interactions